i am stage III CoPD emphysema and use night 02 and for exertion. I am on symbicort & sprivia. My problem lately is muscle ache. Sometimes I feel like I am coming down with flu. I take Motrin but doesn't really help that much. Does anyone else suffer this? Do you think it is side effects from long term medications or side effects COPD. Is there anything I can do because it is hard to do anything when I feel like this. Thanks for your help. .