Roflumilast or Azithromycin to Prevent COPD Exacerbations (RELIANCE)
Initiated February 2020, recruiting
ClinicalTrials.gov Identifier: NCT04069312
About the study
The COPD Foundation is partnering with top pulmonary doctors and researchers at more than 30 institutions across the country to conduct the RELIANCE study. RELIANCE is a clinical trial that compares two medicines currently used for COPD, azithromycin and roflumilast. Research shows that both drugs work to help control COPD attacks and hospitalizations. What we don't know is which drug works better and for whom.
As a partner on RELIANCE, the COPD Foundation will engage the COPD Patient Powered Research Network (PPRN), lead patient and community engagement sessions, and represent the patient perspective throughout all aspects of the study.
Results from clinical trials and clinical guidelines indicate that long-term use of either roflumilast or azithromycin significantly reduces the risk of COPD exacerbations. No studies to date have directly compared long-term roflumilast to azithromycin in patients with COPD, so it is unclear how well they work when compared to each other. The RELIANCE study aims to compare roflumilast and azithromycin head-to-head to determine which therapy is best for the prevention of COPD exacerbations. The RELIANCE project was funded by the Patient Center Outcomes Research Institute. PCORI #PCS-1504-30430
People with COPD have lots of questions.
RELIANCE is designed to help get answers.
If you have COPD and want to participate in research, RELIANCE is a study that compares two medicines (azithromycin vs roflumilast) that may improve the lives of people with COPD.
Go here to learn what is expected from people who join and to see if you are eligible.
COPD affects more than just patients, it affects families.
If you care for someone with COPD and often wonder which COPD treatments will keep loved ones out of the hospital and living a better, more active life, go here to learn what RELIANCE is all about and access resources for COPD caregivers.
A comparative effectiveness trial:
Azithromycin vs Roflumilast for severe COPD
RELIANCE is a multi-site, nationwide clinical research trial designed to compare the real-world effectiveness of long-term oral azithromycin vs. roflumilast to prevent COPD readmissions and mortality after hospital discharge. Click here to learn more:
Become a Community Research Partner!
You can get involved with COPD research by becoming a RELIANCE clinical care Community Research Partner. RELIANCE is low burden and will compensate you. See what's in it for clinicians and review the 3 simple steps to refer patients to RELIANCE.
Should you use long-term azithromycin or roflumilast for care in COPD patients
Preventing COPD Exacerbations:
Talking to patients and experts about deciding between medicines
For more information for patients, caregivers and clinicians click below: