What is COPD?

What is COPD?

Chronic Obstructive Pulmonary Disease (COPD) affects an estimated 30 million individuals in the U.S. Get Screened Today!

Chronic Obstructive Pulmonary Disease (COPD) affects an estimated 30 million individuals in the U.S. Get Screened Today!

• Increased breathlessness
• Frequent coughing (with and without sputum)
• Wheezing
• Tightness in the chest

COPD affects an estimated 30 million individuals in the U.S., and over half of them have symptoms of COPD and do not know it. Early screening can identify COPD before major loss of lung function occurs.

Most cases of COPD are caused by inhaling pollutants; that includes smoking (cigarettes, pipes, cigars, etc.), and second-hand smoke.

Fumes, chemicals and dust found in many work environments are contributing factors for many individuals who develop COPD.

Genetics can also play a role in an individual’s development of COPD—even if the person has never smoked or has ever been exposed to strong lung irritants in the workplace.

Here is more information on the top three risk factors for developing COPD:

COPD most often occurs in people 40 years of age and older who have a history of smoking. These may be individuals who are current or former smokers. While not everybody who smokes gets COPD, most of the individuals who have COPD (about 90% of them) have smoked.

COPD can also occur in those who have had long-term contact with harmful pollutants in the workplace. Some of these harmful lung irritants include certain chemicals, dust, or fumes. Heavy or long-term contact with secondhand smoke or other lung irritants in the home, such as organic cooking fuel, may also cause COPD.

Even if an individual has never smoked or been exposed to pollutants for an extended period of time, they can still develop COPD. Alpha-1 Antitrypsin Deficiency (AATD) is the most commonly known genetic risk factor for emphysema2. Alpha-1 Antitrypsin related COPD is caused by a deficiency of the Alpha-1 Antitrypsin protein in the bloodstream. Without the Alpha-1 Antitrypsin protein, white blood cells begin to harm the lungs and lung deterioration occurs. The World Health Organization and the American Thoracic Society recommends that every individual diagnosed with COPD be tested for Alpha-1. For more information about AATD and how to get tested, visit the Alpha-1 Foundation Website or call 1-877-2 CURE-A1.

Because not all individuals with COPD have AATD, and because some individuals with COPD have never smoked, it is believed that there are other genetic predispositions to developing COPD. Read about the COPDGene™ Study to learn about research to find other genetic causes of Chronic Obstructive Pulmonary Disease.

1 Description from the National Heart, Lung, and Blood Institute (NHLBI) available at: http://www.nhlbi.nih.gov/health/dci/Diseases/Copd/Copd_Causes.html. Website last accessed 3/18/08.

2 Statistics on Alpha-1-related COPD available on the Alpha-1 Foundation website at: http://www.alphaone.org/alphas/?c=01-What-is-Alpha-1-Alphas. Website last accessed 3/18/08.