the following email came to me today,
Lung inflammation in COPD is reduced with a form of vitamin B3
https://copdnewstoday.com/news/form-vitamin-b3-lowers-copd-lung-inflammation-study/
They studied nicotinamide riboside. Read the article.
I wrote to them as follows;
- University of Copenhagen - The Faculty of Health and Medical Sciences
- email@sund.ku.dk
- Kristoffer L. Norheim, Michael Ben Ezra, Indra Heckenbach, Louise Munkholm Andreasson, Lise Lotte Eriksen, Nanna Dyhre-Petersen, Mads Vargas Damgaard, Magnus Berglind, Luca Pricolo, Dayle Sampson, Ryan W. Dellinger, Asger Sverrild, Jonas T. Treebak, Sisse Bolm Ditlev, Celeste Porsbjerg, Morten Scheibye-Knudsen. Effect of nicotinamide riboside on airway inflammation in COPD: a randomized, placebo-controlled trial. Nature Aging, 2024; DOI: 10.1038/s43587-024-00758-1
I have COPD of the type that gets lots of inflammation (phlegm). I do get some from what I breathe, but most of it is from just after eating.I am an 87 year old engineer, not to doctor, but I have read a lot about this problem for several years, and I writing to send some thoughts on my experiences.
Several years ago I did look into NR. If I remember correctly I did not pursue it because it was more expensive than other options, and I was not convinced it would work.
In the process of helping my lady friend get mostly out of Alzheimer’s Disease using a Mediterranean Diet and 4000 mg per day of Longvida Curcumin (UCLA studies) (She got her short term memory, handwriting, driving, self-care, back so she could live by herself and take care of her dog for the next 5 years. It took her 5 months on that treatment to go from 19/30 to 30/30 in the simple memory test. She was still taking 3000mg/day when she had heart failure.(don’t be insulin resistant).
I talked to researchers at Salk Institute to see if the Longvida Curcumin would help my inflammation. Prof. Pam Maher suggested Fisetin (Novusetin as manufactured by Swanson or Doctors Best) using a dosage of 300mg per day. I will explain below how I use it.
Studies from Korea and elsewhere show the action of Fisetin appears to effect NFκB, TNFa, IL6, IL8, and maybe IL1.
I get inflammation almost immediately after eating a meal.(Not a specific type of food, but just about anything I would eat or drink-I have not used alcohol or smoked in the last 31 years – some people say if comes from diary products, but that is not true for me.It can be just about anything I eat. And the reaction time can be from a few seconds to 30 minutes. tried taking fisetin before the meal, but I have found 100 mg immediately after a meal works best for me.I may still get a little phlegm, but I usually can stop it in less than 15 minutes using fisetin. Something must be happening on the top of the stomach.
I am not certain how the fisetin works. Is it electrical (like effect on the vegus nerve) or is it biometric?I am not certain because fisetin is reported to be both an anti-inflammatory and an anti-oxidant. But the reaction on the lungs can be really fast, seconds or minutes, so I expect it is electrical.
That is what I usually use for phlegm. To help my breathing I also use Tadalafil (10 mg every night) and yogurt as a prebiotic about once a week. My O2 reading used to be 89 to92 several years ago. They are now 93 to 96 when sitting at my desk. How could that have happened? Well, fisetin is noted as a senolytic as noted in studies at Mayo Clinic (Dr. Kirkland), and maybe it is getting rid of senescent cells and letting the lung’s own stem cells rebuild the lung’s alveoli as suggested by some researchers. Or, maybe it just because the Tadalafil opens up the blood vessels in the alveoli, or both.
I am writing you about this today in hopes you will consider comparing Fisetin to NR for effectiveness, cost and availability. In the mean time I will consider trying NR.
Your comments would be appreciated.
Richard