I have tried almost every inhaler conceivable. I'm currently using Symbicort and just changed from Spiriva, to Tudorza and now to Seebri. So far the Seebri has had the least side effects, but it's only been a week. I was also using Salbutamol as a rescue inhaler, but develop a bad cough and suffer from severe leg cramps after using it. I am on the search for another rescue inhaler as well. Your opinions are important. Thanks for writing.